Investor Presentaiton

Strong immune responses against A strains. GMTR D29/D01 32 16 8 + 2 sanofi Hemagglutination inhibition titers in 18-64 years old H % Seroconversion 100 80 80 60 60 40 40 20 SPO273 results - Immune response for A strains comparable to SoC - Immune responses for B strains trend lower than SoC 1 0 A/H3N2 A/H1N1 B/YAM B/VIC A/H3N2 A/H1N1 B/YAM B/VIC SP0273 mRNA Flu QIV 48 Vaccines Investor Event Fluzone SD Flublok

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