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Management Presentation

Attractive market fundamentals | Leadership and scale | Multiple growth drivers Margin improvement | Attractive financial outlook | Compelling sustainability story B Maximizing near-term Biosimilars launches Targeted brand Therapeutic areas Originator net sales targeted¹ HumiraⓇ Immunology ~ USD 21bn adalimumab² TysabriⓇ natalizumab Neurology / Immunology ~ USD 2bn ProliaⓇ / XgevaⓇ Bone diseases ~ USD 7bn denosumab / Oncology EyleaⓇ Ophthalmology ~ USD 11bn aflibercept StelaraⓇ ustekinumab Key highlights High Concentration Formulation (HCF), proven supply reliability and strong cost position, differentiating features First and potentially only Biosimilar to market, leveraging experience from Omnitrope success Most advanced industry program, market expansion opportunity in Osteoporosis Strong target product profile, including prefilled syringe at launch Current status HyrimozⓇ launch in the US since July 1, 2023 EU launch expected in Q4 2023 FDA and EMA approval received Expected FDA approval in Q4 2023 and filed in the EU May 2023 Positive Phase III results Immunology ~ USD 10bn Exclusive commercialization rights in Europe and North America Phase III completed in November 2022 Note: The third-party trademarks above are property of their respective owners, 1. Originator sale covered based on Company analysis using Evaluate Pharma; at full year prior to expected market formation year 2. Only pertains to adalimumab high concentration formulation (HCF) 13 Management Presentation SANDOZ
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