Q4 2022 Results slide image

Q4 2022 Results

Existing brands Company overview Financial review Innovation: Pipeline overview Novartis submission schedule Supplementary indications for existing brands 2023 priorities Appendix Innovation: Clinical trials Abbreviations Cardiovascular Immunology Neuroscience Solid tumors Hematology Non-core TA project KisqaliⓇ 2023 ribociclib, LEE011 HR+/HER2- BC (adj) Lutathera 177 Lu-oxodotreotide GEP-NET 1L G3 PiqrayⓇ alpelisib, BYL719 Ovarian cancer XolairⓇ omalizumab, IGE025 Food allergy Y Jakavi® 2024 ruxolitinib, INC424 Pediatrics Acute GVHD JakaviⓇ ruxolitinib, INC424 Pediatrics Chronic GVHD 2025 Cosentyx® secukinumab, AIN457 Y GCA Ly LeqvioⓇ KJX839 Ped Hyperlipidemia ScemblixⓇ ABL001 CML 1L ZolgensmaⓇ AVXS-101 OAV101 SMA IT O denosumab GP2411 BioS anti RANKL mAb Adakveo SEG101 Sickle cell disease, pediatrics aflibercept SOK583 BioS Neovascular age-related macular degeneration Coartem® artemether + lumefantrine, COA566 Malaria uncompl., formula for <5kg AimovigⓇ erenumab, AMG334 Pediatric Migraine CosentyxⓇ secukinumab, AIN457 Lupus Nephritis KesimptaⓇ2 ofatumumab Multiple sclerosis, pediatrics LeqvioⓇ KJX839 CVRR-LDLC BeovuⓇ brolucizumab, RTH258 Diabetic retinopathy PromactaⓇ eltrombopag, ETB115 Radiation sickness syndrome AtecturaⓇ indacaterol + mometasone, QMF149 Asthma, pediatrics 1. 177 Lu-dotatate in US. 2. Kesimpta and Mayzent: Pediatric study in multiple sclerosis run in conjunction (NEOS). 58 Investor Relations | Q4 2022 Results ≥2026 න MayzentⓇ 2 siponimod, BAF312 Multiple sclerosis, pediatrics RydaptⓇ midostaurin, PKC412 Acute myeloid leukemia, pediatrics ScemblixⓇ ABL001 CML, 2L, pediatrics NOVARTIS | Reimagining Medicine
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