Investor Presentaiton

FY 2021 Revenue (FTE¹) $6,500.1 Noninterest Expense 4,535.9 Provision for Credit Losses (81.5) $1,545.3 Diluted Earnings per Share $7.14 Return on Equity² 13.9% Pre-Tax Margin 1,2 31.5% Expense to Trust Fee Ratio² 104% RESULTS & KEY METRICS: FULL YEAR 2021 $ in millions (except EPS and as noted) Net Income The current year includes the following items: Pre-tax pension settlement related charges of $27.8 million Pre-tax severance related charges of $6.1 million in connection with a reduction in force $13 million pre-tax gain relating to property sales Net one-time tax benefits of $13.9 million primarily relating to a lower net tax impact from international operations ■ The prior year included the following items: Pre-tax severance-related charges of $55.0 million in connection with a reduction in force Pre-tax charge of $43.4 million related to a corporate action processing error % Change Vs. FY 2020 +6% +4% N/M +28% +31% 11.2% 27.1% 109% Assets under Custody / Administration³ (in billions) $16,249 +12% Assets under Custody³ (in billions) $12,612 +12% Pre-tax occupancy charge of $11.9 million related to an early lease exit arising from a workplace real estate strategy Global Custody Assets³ (in billions) $8,238 Assets under Management³ (in billions) $1,607 Tax expense of $26.8 million related to the reversal of tax benefits previously recognized through earnings 1 Revenue and pre-tax margin stated on an FTE basis is a non-GAAP financial measure. A reconciliation of these measures to reported results prepared in accordance with U.S. generally accepted accounting principles (GAAP) is included in the Appendix on page 12. 2 Actual numbers for all periods, not % change. +11% +14% 3 Client assets for the current quarter are considered preliminary until the Form 10-K is filed with the Securities and Exchange Commission. northerntrust.com | 2022 Northern Trust 8

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