23andMe Investor Presentation Deck

MOA 1 MOA 2 ¹1473 Dual MOA: Effector Enhanced Antibody Binds to Tumor Cell Surface ULBP6/2/5 to Bolster NK Cell Antitumor Activity via ADCC NK cell 23ME-01473 Activating receptor NKG2D NK cell FcyR Shed o Tumor ULBP6 O cell Surface MICA Surface ULBP2/5/6 Cytotoxic mediators Immune cells Tumor amount in the well (Mean GFP expression/ well) ADCC increases tumor cell killing 0 Green (GFP) Tumor Cells 20 40 60 80 Time elapsed (hour) 100 NKG2D activation 120 Isotype Effector enhanced CTRL anti-ULBP6 Effector attenuated MOA1 NKG2D activation + ADCC Copyright © 2024 23andMe, Inc. X 23ME-01473 Effector enhanced MOA1+2 23and Me 33

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