23andMe Investor Day Presentation Deck
Human Genetics has the Potential to Double the Probability of
Success in Drug Development
Huw
000
Reasons for failure
Wrong target
• Hypothesized target not a critical node in disease pathogenesis
• Safety issues associated with target
Wrong drug
Insufficient affinity/avidity; off-target effects
• Poor PK/tissue penetration/inadequate dosing
Wrong outcomes
• Clinical outcome measure not related to biology of target
• Clinical outcome measure not relevant in trial population
Our rich database
and translational
focus has the
potential to mitigate
these and increase
probability of
success
Wrong patients
• Patients not properly stratified according to molecular, pathophysiological, or clinical heterogeneity
• Trials underpowered to detect an effect in the right subset
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