ATAI Investor Presentation Deck

CIAS & Schizophrenia Opportunity Overview Cognitive impairment associated with Schizophrenia & Schizophrenia often lead to individuals making choices they feel are out of their control Cognitive Impairment Associated with Schizophrenia (CIAS) & Schizophrenia CIAS & Schizophrenia in numbers There is no single test for Schizophrenia, with the conditional being diagnosed after assessment by a mental health specialist ~24m Global sufferers of Schizophrenia¹ 15th Leading cause of disability worldwide (2016)² ~$155bn U.S. economic burden from adults with CIAS or Schizophrenia (direct + indirect costs)³ HUGE NEED FOR DEVELOPMENT -20 yrs -30% ~80%6 (1) World Health Organization (2) Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: al systematic analysis for the Global Burden of Disease Study 2016 (3) Cloutier et al, The economic burden of schizophrenia in the United States in 2013. J Clin Psychiatry 2016;77(6):764-771 (4) Bora et al, Cognitive Impairment in Schizophrenia and Affective Psychoses: Implications for DSM-V Criteria and Beyond 0 Lost life expectancy4 Schizophrenia results in a life expectancy of approximately 20 years below that of the general population Low treatment rate5 Only -30% of people with psychosis receive specialist mental health care Cognitive impairment is very common Cognitive impairment is a common and major cause of disability in schizophrenia, with more than 80% of patients showing significant impairment FDA approvals for CIAS Currently there are no FDA approved treatments for CIAS 20 (5) World Health Organization (6) Bora et al, Cognitive Impairment in Schizophrenia and Affective Psychoses: Implications for DSM-V Criteria and Beyond

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