Investor Presentaiton

Estetrol: the early-life native estrogen Estrogens made by the body Estradiol (E2) Estriol (E3) Estrogens made outside the body Made in ovaries during reproductive years E3 E4 ΕΙ Produced by the foeto-placental unit Synthetic Estrogens (e.g. Ethinyl estradiol) Produced for medical use e.g. in birth control pills Phytoestrogens Found in plants, E1 e.g. in soybeans Estrone (E1) Produced in liver, peripheral tissues and ovaries Adult Estrogens Estetrol (E4) Produced by the human fetus Fetal Estrogens Endocrine disrupting Xenoestrogens agents coming from man-made products 0000000 0000000 0000000 0000000 Mithra Investor Presentation - November 2023 12

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