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Investor Presentaiton

62 Investor presentation Full year 2022 Novo NordiskⓇ Large opportunity for activating more people with obesity to seek treatment and increasing the number of prescribers ONCE-WEEKLY wegovy® semaglutide injection 2.4 mg 70% WegovyⓇ patient characteristics in the US 31% 81% 37.8 of patients new to anti- obesity medication¹ of patients are female Average BMI of patients have ≥3 co- morbidities Of the people with overweight or obesity in the US, almost 90% have a weight-related comorbidity BMI 140 (million of people) 27-30 30-35 35-40 (43) ≥40 Total (52) (25) (20) (140) No obesity-related comorbidity¹ 7 6 2 2 17 million people with a BMI > 27 Any obesity-related comorbidity Hereof metabolic syndrome³ 36 46 23 18 123 21 26 14 14 12 72 1Individuals without any of the following obesity related conditions: T2DM, Pre-diabetes, NASH, NAFLD, obstructive sleep apnea, osteoarthritis, PCOS, ASCVD, Heart failure, asthma, urinary incontinence, hypertension, chronic kidney disease stg. 3 or 4, musculoskeletal pain, dyslipideamia, metabolic syndrome; 3 Metabolic syndrome defined as two or more of dyslipidaemia; hypertension; prediabetes OR type II diabetes Source: Novo Nordisk real world research; National Health And Examination Survey (NHANES) cycles 2015-2016 and 2017-2018
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