Investor Presentation First Nine Months of 2022

128 Investor presentation First nine months of 2022 Insulin market size and volume market share in Rest of World Insulin market share and market size (DKK billion) Total 41% Long- acting 62% Fast- acting 2 Premix 83% 2 66% Human 2 58% 5 Novo Nordisk Competitors Rest of World Market growth A Market share Insulin volume: Market share 80% 20% 12 7.3% +1.5% 60% 15% 57% 10% 10.5% +2.3% 40% 5% 5.4% +1.2% 20% 5.9% +2.3% 0% Aug 2019 4.3% +1.1% Source: IQVIA, Aug 2022; LHS graph - Value, RHS Graph - Volume, MAT; Share of growth not depicted due to too high numbers; NN: Novo Nordisk 0% -4% -5% -4% -10% Aug 2022 -NN market share -Market growth (right axis) -NN growth (right axis)

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