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Investor Presentaiton

6 IDEAYA Precision Medicine Oncology Platform Fully-Integrated Target, Biomarker, Drug Discovery and Translational Capabilities Target & Biomarker Discovery and Validation . • . Bioinformatics, including Al Algorithms Dual CRISPR, CRISPR, Chemogenomics Genetically Engineered Models Drug Discovery and Pharmacological Validation Key emerging novel targets identified, such as Werner Helicase, Pol Theta Helicase and PARG DECIPHER™ - Dual CRISPR SL Library in DDR Cell Lines in collaboration with UCSD PAGEOTM - Paralogous Gene Evaluation in Ovarian in collaboration with Broad Institute Machine Learning and Multi-Omics platform Structure Based Drug Design Small Molecule Chemistry Protein Degrader Capabilities Translational Research and Opportunity Expansion Genomics - DNA and RNA Analysis Proteomics - Protein Expression Profiling Tissue (IHC, IF) and Liquid Biopsies Analysis Crystal structures for SL discovery programs obtained to enable structure-based design INQUIRE™ Chemical Library - proprietary, expert-curated small-molecule library • HARMONY™ Machine-Learning engine empowers drug discovery platform Differentiated clinical / candidate compounds discovered, including IDE397, IDE161 and GSK101/IDE705 (Pol Theta Helicase) • . . Translational research to define clinical biomarkers Opportunity expansion through broad cell panel screening Pharmacodynamic biomarker analysis to confirm target modulation and correlation with clinical activity IDEAVA BIOSCIENCES
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