TROPION-Lung01 Study Design and Baseline demographics

PFS in Key Subgroups Age at randomization <65 years Sex ≥65 years Male Female 60/95 Race Asian Events/n Dato-DXd Docetaxel 118/162 115/155 95/137 103/150 136/183 158/210 77/116 76/119 82/120 HR H 0.67 0.83 0.79 0.71 0.77 Non-Asian Smoking status Never Former/current Brain metastasis at With baseline Without 131/172 36/61 33/52 177/238 184/251 33/50 31/47 180/249 187/258 129/177 0.76 0.67 0.77 0.64 0.76 Non-squamous Histology Squamous 156/229 168/232 50/73 0.63 Actionable genomic Absent 57/70 189/252 184/255 1.38 0.84 alterationsa Present 24/47 34/50 0.38 *Regardless of histology. 0 0.5 1.5 2 Hazard ratio 2.5 Daiichi-Sankyo 10

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