Investor Presentaiton

NET INTEREST INCOME Average Earning Assets ($ in billions) $140.6 $131.2 $142.0 $148.8 $144.0 1.05% 1.00% 0.97% 0.98% 0.99% NII (FTE¹) in millions 4Q 2020 $ 345.1 1Q 2021 $ 346.7 2Q 2021 $ 343.9 3Q 2021 $ 357.1 4Q 2021 $370.6 Loans & Leases Deposits w/ Banks Securities ■ Net Interest Income (FTE¹) was up 7% year-over- year and 4% sequentially. Net interest margin (FTE) was 0.99%. Average Earning Assets were up 13% year-over- year and 3% sequentially. ■ Average Total Deposits were up 18% year-over- year and 5% sequentially. ■ Net Interest Margin decreased 6 basis points from the prior-year quarter primarily due to lower average interest rates, partially offset by a favorable balance sheet volume and mix shift. Net Interest Margin increased 1 basis point versus the prior quarter primarily due to a favorable balance sheet volume and mix shift. NIM (FTE¹) Fed Deposits & Other 1 Net interest income and net interest margin stated on an FTE basis are non-GAAP financial measures. A reconciliation of these measures to reported results prepared in accordance with U.S. GAAP is included in the Appendix on page 12. northerntrust.com | 2022 Northern Trust 6

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