Kymera Investor Day Presentation Deck

Multiple Proinflammatory Transcripts Are Upregulated and Correlate with IRAK4 Protein Levels in HS Skin Lesions Chemokines Cellular Cytotoxicity Cytokines & Cytokine Signaling Cytokine Receptors TLRs Myddosome Inflammasome Prostaglandins KYMERA Lesion -1 Peri-lesion Non-lesion Scaled Expression 0 Healthy 1 CCL2 CCL20 CSF3 CXCL1 CXCL2 CXCL6 CXCL8 CXCL11 CXCL13 GZMB PRF1 IFNG IL10 IL1B IL32 IL36G IL6 IRF7 SOCS3 TNF IL2RA IL2RB IL18RAP MYD88 TLR1 TLR2 TLR3 TLR4 TLR6 TLR8 TLR9 NLRP3 PTGS2 ©2021 KYMERA THERAPEUTICS, INC. Chemokines Cytokines & Cytokine Signaling Cytokine Receptors Cellular Cytotoxicity TLRs Myddosome IRAK4 Lesion Correlation VS. Non-lesion IF MS Inflammasome Prostaglandins CCL2 CCL20 CSF3 CXCL1 CXCL2 CXCL6 CXCL8 CXCL11 CXCL13 IFNG IL10 IL1B IL32 IL36G IL6 IRF7 SOCS3 TNF IL2RA IL2RB IL18RAP GZMB PRF1 MYD88 TLR1 TLR2 TLR3 TLR4 TLR6 TLR8 TLR9 Spearman correlation log₂ (fold change) NLRP3 PTGS2 IF: immunofluorescence; MS: mass spectrometry KYMERA R&D DAY - December 16th, 2021 1.0 0.5 0.0 -0.5 -1.0 0 Upregulation of TLRs, IL-13/IL-36, MYD88, and multiple additional drivers of inflammation that all correlate with IRAK4 protein expression Highlights potential of IRAK4 targeting to treat diseases like HS characterized by marked pleiotropic inflammation Alavi et al., Society for Investigative Dermatology Annual Meeting, 2021 PAGE 23

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