Investor Presentation Full Year 2021

43 Investor presentation Full year 2021 Insulin market size and volume share of growth and market share Insulin market share and market size (DKK billion) Total 44% Long- Acting 37% Fast- 52% 89 88 Acting 68% Premix 17 34% Human 23 131 Novo Nordisk Competitors Market growth A Market share 260 -2.4% -0.5% 80% Insulin volume: market growth and market share Novo NordiskⓇ 15% 12% 60% -1.4% -0.6% 47.1% 9% 40% -2.6% -0.4% 6% 20% 3% -5.7% +1.9% 0% 0% Nov Nov 2018 2021 -NN market share -5.1% -1.3% Source: IQVIA, Nov 2021, LHS graph - Value, RHS Graph - Volume, MAT, all countries; Share of growth not depicted due to too high numbers; NN: Novo Nordisk Market growth (right axis) NN growth (right axis)

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