Investor Presentation Full Year 2021

104 Investor presentation Full year 2021 Insulin market size and volume share of growth and market share in Region China Region China Insulin market share and market size (DKK billion) Market growth A Market share Insulin volume: market share 80% 50% 14 11.6% +1.8% Total 49% 24% Long- acting 81% Fast- acting 2 Premix 80% 4 39% Human 3 6 Novo Nordisk Competitors Source: IQVIA, Nov 2021, LHS graph - Value, RHS Graph - Volume, MAT; NN: Novo Nordisk 40% 60% 55% 17.6% +5.7% 51% 30% 40% 20% 15.4% +0.1% 20% 7% 10% 12.2% +1.8% 0% 0% Nov Nov NN market share 2018 2021 -NN share of growth -1.5% -3.4% Market growth (right axis) -NN growth (right axis)

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