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Reimagining Medicine

Company overview Financial review Innovation: Pipeline overview 2023 expected key events Regulatory decisions Cosentyx® HS CosentyxⓇ 2 ml Al Cosentyx® IV Leqvio® Hypercholesterolemia Submissions Iptacopan PNH (US/EU/JP) PluvictoⓇ mCRPC, pre-taxane (US) Readouts KisqaliⓇ HR+/HER2- BC (adj) Iptacopan IgAN Ph3 Ph3 starts Iptacopan C3G Ph3 Iptacopan in IC-MPGN LeqvioⓇ CVRR primary prevention lanalumab in immune thrombocytopenia lanalumab in systemic lupus erythematosus 2023 priorities Appendix Innovation: Clinical trials Abbreviations H1 2023 H2 2023 EU US US US JP, China US/EU JP Ph3 Ph3 Ph3 US NATALEE Ph3 FIR APPLAUSE-IgAN Ph3 Ph3 APPEAR-C3G Ph3 Ph3 HS hidradenitis suppurativa. PNH - paroxysmal nocturnal hemoglobinuria. mCRPC metastatic castration-resistant prostate cancer. FIR - first interpretable results. IgAN-immunoglobulin A nephropathy. C3G complement 3 Glomerulopathy. IC-MPGN - immune complex membranoproliferative glomerulonephritis. 51 Investor Relations | Q4 2022 Results INNOVATION U NOVARTIS | Reimagining Medicine
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