Novavax Global Commercial Operations and COVID-19 Vaccine Update

Primary study endpoint achieved in adolescents Neutralizing antibodies Adolescents 12 - 17 years Main Study 18 - 25 years Geometric Mean Titer (GMT) (95% CI) 3,860 (3,423 - 4,352) 2,611 (2,367 -2,882) Geometric Mean Ratio (GMR) 1.5 (95% CI) (1.3 - 1.8)* *Noninferiority was achieved if the following 3 pre-specified criteria were met simultaneously: 1) Lower bound of two-sided 95% CI for the ratio of GMTS (GMT12-17yo/GMT 18-25yo) > 0.67; 2) Point estimate of the ratio of GMTS ≥ 0.82; and 3) Lower bound of the two-sided 95% CI for difference of SCRS (SCR12-17yo - SCR18-25yo) was > -10%. novavax WT neutralization GMT (95% CI) Study 301: 1,078 (968 - 1,201) Study 302: 1,133 (999 - 1,285) © 2023 NOVAVAX. All rights reserved. 37

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