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Investor Presentaiton

ENHERTU Revenue FY2023 Q1 Results YOY FY2023 Forecast (Bn JPY) <Reference> YoY Total Consideration Daiichi-Sankyo Product Sales 81.7 50.4 320.0 112.5 Japan US Europe ASCA 4.4 1.9 19.9 8.2 51.6 31.5 195.1 50.5 17.8 11.1 75.8 38.8 8.0 5.8 29.2 15.1 *1 *1 Upfront payment Regulatory milestone payment US HER2+ Breast Cancer 3L EU HER2+ Breast Cancer 3L 2.5 9.8 149.0 *1 *1 2.1 -1.3 11.6 -15.1 136.3 0.2 0.1 US HER2+ Gastric Cancer 2L + 3L 0.2 I I I 0.9 13.7 0.5 7.9 0.8 12.1 US HER2+ Breast Cancer 2L 0.2 -2.6 0.9 -2.6 13.1 EU HER2+ Breast Cancer 2L 0.2 0.2 0.7 -2.0 10.1 *1 Revenue recognized in each period *2 Converted with assumed forex rate for FY2023 of 130 JPY to 1 USD US HER2-low Breast Cancer (post-chemo) 0.5 0.5 1.8 -5.5 27.7 EU HER2-low Breast Cancer (post-chemo) 0.3 0.3 1.3 -3.9 19.8 EU HER2+ Gastric Cancer 2L 0.1 0.1 0.3 -0.9 4.8 US HER2 Mutant NSCLC 2L 0.3 0.3 1.1 -3.4 17.3 EU HER2 Mutant NSCLC 2L 3.2 3.2 9.8 *2 Quid related payment Sales milestone payment *1 0.3 1.1 *1 17.2 *3 Milestone of 200Mn USD for achieving annual product sales of 2 Bn USD in co- commercialization territory with AstraZenceca. (Total amount to be recognized in FY2023) Ref. Total sales milestone payment: 1.75 Bn USD (Max) *3 26.0 12.8 39.2 Total 86.6 49.2 368.6 110.2 341.7 11
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