2022 Highlights and ESG Progress

Global businesses Corporate & Investment Banking SCIB's client centric transformation from lenders to strategic partners is yielding strong results ⚫ Further diversified business model across clients, geographies and products. Accelerated capital rotation ⚫ Robust operating performance driven by double-digit growth in all core businesses, especially Markets, GDF and GTB • • Wealth Management & Insurance Strong growth in contribution to Group profit on a like-for-like basis (+18%) in a challenging market environment Private Banking: recognized as a top 3 Best Global Private Bank with a record year in results and cross-border business SAM showed resilience market turmoil maintaining contribution to profit level Insurance: sustained growth in gross written premiums: +24% Total fees €1,988mn +9% Profit €2,805mn +31% ROTE 22.0% +4.5pp AuMs Total fees¹ €401bn -3% €3,689mn +3% ROTE 59.7% +5.1pp P&L* Q4'22 % Q3'22 2022 % 2021 % 2021² P&L* Q4'22 % Q3'22 2022 % 2021 % 2021² Total revenue 1,798 -3.1 7,395 27.4 31.6 Total revenue 701 5.0 2,608 12.1 16.4 Net operating income 935 -17.1 4,497 35.0 38.8 Net operating income 417 1.7 1,566 14.8 18.1 Underlying att. profit 441 -38.6 2,805 31.0 32.7 Underlying att. profit 301 2.1 1,118 15.3 18.8 (*) € mn and % change in constant euros. Contribution to profit 3 738 3.9 2,728 9.7 15.7 (*) € mn and % change in constant euros. Santander Note: 2022 data and YoY changes (fees, profit and commercial activity in constant euros). (1) Including fees generated by asset management and insurance ceded to the commercial network; +4% excluding insurance one offs in 2021. (2) % change in current euros. (3) Excluding insurance one-off in 2021: contribution to the profit: +18%; total revenue: +22%, net operating income: +34% and attributable profit: +36%. 47

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