BioNTech Investor Day Presentation Deck

Absolute frequency of genes selected for iNeST¹ vaccination across BioNTech trials 2 iNeST selection frequency [absolute] 150 140 50 40 30- 20 10- 0 28 7 6 5 1,400+ patients screened 4 1 Collaboration with Genentech 2 GO39733, GO40558, BNT122-01, ML41081. 3 28 different cancer indications ~ 1,700 tumor samples processed 2 >12.500 neoantigens selected The long tail of individual targets Genes grouped by iNeST selection frequency [absolute] P - 420+ 1 patients treated Target discovery BIONTECH 26

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