Investor Presentation

Expanding addressable market now $8.5B; $23B total market Taking share, creating new markets, and delivering industry-leading revenue growth PROTEINS & AFFINITY RESINS Our market share: ~6% Our 3-year CAGR (2019-2022): >15% PROCESS ANALYTICS Our market share: 4%-5% Our 2-year CAGR (2020-2022): >25% R REPLIGEN $2.0B 24% $1.4B 17% $8.5B TAM $950M 11% CHROMATOGRAPHY Our market share: ~13% Our 3-year CAGR (2019-2022): >25% $4.1B 49% FILTRATION Our market share: ~12% (from 9%) Our 3-year CAGR (2019-2022): >60% Repligen Market Share 2022 9%-10% of TAM 2022 Y/Y franchise-level revenue for market share calc reflects franchise level growth as of our Q4 earnings call Feb. 22, 2023. 11

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