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Investor Presentaiton

Investor Presentation First nine months of 2018 Slide 54 Stable global insulin volume growth North America Region China Regional insulin volume growth Region Europe Region J&K 25% 20% 15% 10% Regional insulin volume market split Region AAMEO North America Region LATAM Region China World 100% 80% 60% 40% 5% 20% 3% 0% Aug 2013 0% Aug 2018 Reg: Region; J&K: Japan & Korea; AAMEO: Africa, Asia, the Middle-East and Oceania; LATAM: Latin America Note: Data is sensitive to changes in IQVIA data collection and reporting methodology Source: IQVIA monthly MAT Aug, 2018 volume figures changing diabetes® Region Europe Region J&K Region AAMEO Region LATAM 3% 3% 10% 21% Aug 2013 Note: Data is sensitive to changes in IQVIA data collection and reporting methodology Source: IQVIA monthly MAT Aug, 2018 volume figures 33% 30% Aug 2018 novo nordisk

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