Investor Presentaiton

7 AZP-3813 Pharmacokinetics in Beagle Dogs Increasing doses of AZP-3813 produce linear increases in blood concentration 1000 0.1mg/kg AZP-3813 (ng/mL) 800- 600- 400- 200 0 0 20 40 60 80 Hours 10000- AZP-3813 (ng/mL) 8000- 6000 4000 2000 1.0mg/kg 100000 10000 1000 100 10 mg/kg 10 1 mg/kg AZP-3813 (ng/mL) • 0.1 mg/kg 1 0 20 40 Hours 60 Η 80 80 Increasing doses of AZP-3813 produce parallel elimination curves 0 0 20 40 60 80 Hours 80000- Dose Half-Life (h) AZP-3813 (ng/mL) 10mg/kg 60000- 0.1mg/kg 15.1 Mean circulating half-life = 14.2 + 0.47 hours 40000 1.0mg/kg 13.2 20000- 10mg/kg 14.3 0 0 20 40 60 80 Hours AMOLYT PHARM A

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