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Investor Presentation

112 Investor presentation First six months of 2022 EMEA at a glance EMEA Million Diabetes trend Diabetes market by value and Novo Nordisk market share Novo Nordisk reported sales 300 DKK billion 25% First half of 2022 Sales (mDKK) Growth² Total GLP-13 6,815 35% 250 100 80% 19% I GLP-1 Long-acting insulin4 3,776 7% I 33.0%¹ Premix insulin5 1,348 -11% 200 80 60% Fast-acting insulin 3,391 2% 150 60 60 Human insulin 3.2%1 1,043 -8% Insulin 260 40% Total insulin 9,558 1% 100 40 195 Other Diabetes care? 361 3% 158 50 20 OAD 20 11.1%1 20% Diabetes care 16,734 12% Obesity care8 1,516 78% 0 0 0% 2021 2030 2045 May 2017 May 2022 Diabetes & Obesity 18,250 16% care Population with diabetes Diabetes growth rate GLP-1 MS -Insulin MS -OAD MS Rare disease⁹ Total 3,489 -5% 21,739 12% Diabetes trend estimates based on the following International Diabetes Foundation defined regions: Africa, Europe, Middle East and North Africa, South and Central America, South East Asia and Western Pacific Source: International Diabetes Federation: Diabetes Atlas 10th Edition 2021; EMEA: Europe, Middle East and Africa 1 CAGR calculated for 5-year period; Competitor insulin value market shares, as of May 2022: Novo Nordisk 48%, Sanofi 32% and Eli Lilly 16%; Competitor GLP-1 value market shares, as of May 2022: Novo Nordisk 59%, Eli Lilly 38% and AstraZeneca 3%; OAD: Oral anti-diabetic; MS: Market share; Source: IQVIA MAT, May 2022 value figures 2 At Constant exchange rates; 3 Comprises VictozaⓇ, Ozempic®, and RybelsusⓇ; 4 Comprises Tresiba®, XultophyⓇ and Levemir®; 5 Comprises RyzodegⓇ and NovoMix®: 6 Comprises FiaspⓇ and NovoRapid®: 7 Comprises Novo NormⓇ and needles; 8 Obesity care comprises SaxendaⓇ and Wegovy®: 9 Comprises primarily NovoSeven®, Novo Eight® NovoThirteen®, Esperoct®, Refixia®, Norditropin, Vagifem® and ActivelleⓇ Source: Quarterly company announcement
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