Taysha IPO Presentation Deck

SLC13A5 deficiency results in persistent seizures and developmental delays SLC13A5 deficiency is caused by mutations in the SLC13A5 gene Epileptic episodes start within the first week of life and consists of severe, prolonged episodes Severe difficulty with speech production, movement and coordination problems and tooth enamel abnormalities are common - The estimated prevalence of SLC13A5 is 225 patients in the US and EU, which is likely higher due to patients being misdiagnosed as cerebral palsy AAV9 IAT hSLC13A5 + Intrathecal delivery F. 65

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