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Novartis Investor Presentation

New Novartis: Our strategy Our focus > Core Therapeutic Areas Technology platforms Priority geographies Capital allocation / structure Our priorities Conclusion Abbreviations Strong positioning in Cardiovascular, the leading cause of death and disability 1. Core TAs - Cardiovascular Phase 1 Phase 2 Phase 3 Registration 8 Novel approaches that aim to improve HF outcomes Dyslipidemia treatments that improve CV morbidity/mortality in identifiable high-risk groups with high unmet need Population health approach, initially with NHS. agreement for broad and rapid access to Leqvio® Chronic and acute renal specialty indications with high unmet need and limited/no targeted therapies Disease modifying therapies for metabolic disorders Selected compound (indication) LeqvioⓇ (Hyperlipidemia) LeqvioⓇ (CVRR-LDLC) Leqvio® (Primary prevention)1 Pelacarsen (Lp(a)) XXB750 (Cardiovascular diseases) Iptacopan (IgAN) Iptacopan (C3G) Disease area Cardio Renal Iptacopan (IMN) Iptacopan (Others) TIN816 (S-AKI)² Metabolic MBL949 (Obesity) Note: Bars in Gantt chart indicate current phase of development 1. Phase 3 not yet started 2. Phase 2 initiating Novartis Investor Presentation | September 22, 2022 U NOVARTIS | Reimagining Medicine
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