Ocuphire Pharma Investor Presentation Deck

Change in DRSS Score by Patient by Eyes 0% Patients in APX3330 Treatment Group had Binocular 3-Step Worsening Improvement Change in DRSS Worsening -6 -2,-2 -4 -2,-2 -1,-3 -3 -2 2 3 4 -3,-2 6 0,-3 -1,-1 -1,-1 -1,-1 APX3330 Binocular Change from Baseline @ Week 24 (MITT LOCF) -1,0 0,-1 -1,0-1,0 0,-1 Presented on 8/1/23 at ASRS 0,0 0,0 0,0 0,0 0,0 0,0 0,0 0,00 0,00 0,0 0,0 0,0 ¹,1 1,1 -1,1 Patients (n=47) DRSS Bar Legend Green: Both Eyes Improving Blue: 1 Eye Improving and 1 Eye Unchanged Purple: 1 Eye Improving and 1 Eye Worsening Orange: no change OU Gray: 1 Eye Worsening and 1 Eye Unchanged Red: Both Eyes Worsening ▬▬▬▬▬▬▬▬▬▬ 1,0 1,0 0,1 0,1 2,-1 -1,2 1,0 1,0 1,0 0,1 0,1 2,-1 IIII 0,2 1,1 1,1 0,2 1,1

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