Investor Presentaiton

IDEAYA Functional Genomics and Synthetic Lethality Platform S Novel Target and Biomarker Discovery and Validation Target and Biomarker Discovery & Validation Platform IDEAYA Functional Genomics Platform integrates proprietary and public data sets with orthogonal and complementary content Bioinformatic analysis enables identification and validation of synthetic lethal target / biomarker interactions across vast datasets Robust SL interactions validated genetically (Dual CRISPR, paralogues, isogenic pairs, CRISPR/siRNA), pharmacologically and in vivo Data-to-Knowledge Enterprise fueled by multi-omic patient and molecular data across public, partnership and proprietary data sets via IDEAYA Bioinformatics Platform Public Data Partnership Data Proprietary Data DECIPHER™ Dual CRISPR SL Library in DNA Damage Repair (2) PAGEO™M Paralogous Gene Evaluation in Ovarian Cancer (1) Я я 1 Paralog A Paralog B +/- Inhibitor Machine Learning and Multi-Omics Integration Dimensionality Reduction Clustering Methods -4 -10 1 Feature Selection Enrichment Analyses Predictive Modeling Evaluation of DNA Damage Targets synthetic lethal with tumor suppressor or oncogenes Evaluation of SL targets in context of functionally redundant paralogous genes in ovarian cancer Д Partnership Datasets Public Databases TCGA BioPortal CCLE Targets, Biomarkers and MOA Target Evaluation and Prioritization depmap portal FOUNDATIONINSIGHTS TM PROJECTGENIE Genomics Evidence Neoplasia Information Exchange Project Achilles MSK-IMPACT™ Kettering Memorial Ste 7 (1, 2) IDEAYA Proprietary Libraries and Datasets - Strategic Collaborations with Broad Institute (1) and UC San Diego(2) IDEAVA BIOSCIENCES

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