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Pharma Update

Roche Our achievements Roche is continuously shifting the standard of care A legacy of patient and business impact... Blockbuster drugs in 2022, up from 7 in 2012 in neurology and hemophilia A¹ 16 #1 #3 in oncology1 #1 in in vitro diagnostics1 #1 top pharma as ranked by rare. #1 disease patient groups² Pharma in Al readiness³ ...with a track record of establishing standard of care across new therapeutic areas OCREVUS ocrelizumab FOR N 300MG/10ML First and only therapy approved for RMS/PPMS HEMLIBRA emicizumab-kxwh injection for subcutaneous use 150 mg/mL First and only prophylactic treatment for hemophilia A with/without inhibitors VABYSMO First bispecific antibody in AMD and DME 60 mg powder for solution Evrysdi risdiplam First-in-class splicing modifier for the treatment of SMA 1 based on FY 2022 sales (Evaluate/Bloomberg); 2Patient View, 2023; 3CBInsight, 2023; Al-artificial intelligence; RMS=relapsing; PPMS-primary progressive multiple sclerosis; AMD-age-related macular degeneration; DME=diabetic macular edema; SMA-spinal muscular atrophy 13
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