Investor Presentation

35 Investor presentation First six months of 2022 Novo NordiskⓇ People with diabetes have increased mortality risk, and the diabetic population is expected to increase to 784 million by 2045 Diabetes is associated with shorter life expectancy and lower quality of life Million The number of people with diabetes is expected to increase 32% by 2045 1,000 • Life expectancy 8 years shorter¹ Diabetes I • Driven by 200% increased risk of all cause mortality¹ 800 +32% 784 63 643 600 537 57 286 • 70% of people with diabetes die from 51 227 CVD atherosclerotic CVD² 400 187 • 150% increase in risk of stroke³ 175 164 141 200 260 • Higher likelihood of neuropathy, 158 195 Organs retinopathy, limb amputation, cancer and cognitive dysfunction4 0 2021 2030 2045 EMEA Region China ROW North America 1 Diabetes Care 2017 Mar; 40 (3): 338-345; 2 https://www.who.int/cardiovascular_diseases/en/; 3 https://www.diabetes.org/diabetes/complications.; CVD: Cardiovascular disease; OAD: Oral anti-diabetic; 4 Diabetes Care 2005 Jan;28(1):164-176 Source: International Diabetes Federation: Diabetes Atlas 10th Edition 2021 EMEA: Europe, Middle East, Africa; RoW: Asia Pacific, Latin America

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