Investor Presentaiton

Rigosertib identified as lead PLK1 inhibitor in RDEB CSCC Rigosertib Concentration 48 hrs exposure DMSO 0.01uM 0.1uM 1uM 10uM 100uM Primary Foreskin Keratinocytes Primary Breast Keratinocytes Primary RDEB 85 Keratinocytes Primary RDEB 93 Keratinocytes RDEB 2 SCC Keratinocytes RDEB 3 SCC Keratinocytes RDEB 4 SCC Keratinocytes 22 Clin Cancer Res March 7 2019 DOI:10.1158/1078-0432.CCR-18-2661. PMID: 30846478 EID 0 ONCONOVA THERAPEUTICS

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