Kymera IPO Presentation Deck

% IRAK4 (Control) + SEM KYMERA 150 100 50- KT-474: Specific IRAK4 Degradation Degradation in Human Monocytes KT-474 KT-5653 (Negative Control) Log [Compound] (µM) • Calculated DC50 of 2.1 nM and E3 ligase dependent degradation of IRAK4 in human immune cells IRAK4 was only protein of over 10,000 to be degraded by KT-474 in human immune cells at concentration 10-fold above the DC p-value (-Log 10) 3. 2.5 2 1.5 0.5 0 Selectivity in Human PBMC 10xDC RAKA 24hr -2 -1.5 -1 -0.5 0 0.5 1 1.5 2 Protein Level Fold Change (Log2)

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