Ocuphire Pharma Investor Day Presentation Deck
P
85
VEGA-1: Mean Pupil Diameter Over Time
Achieved Optimal Pupil Size in Nyxol+LDP (& Nyxol) Consistent with 3-line Near Vision Gain
Mean Pupil Diameter (mm)
5
4
1
4.5
4.5
+4
4.5
4.4
Daily Evening
Nyxol Dosing 12 hr
minimum interval
to Time 0
Baseline
***
***4.5
4.3
3.2
3.1
0
***
T
4.5
*** 3.2
HH
3.0
2.4
***
***
**
1
Placebo (n=43)
4.4
3.2
2.5
2.1
VEGA-1 Phase 2 Trial
Best Eye (PP Population)
Mean Photopic Pupil Diameter
***
***
**
2
4.3
3.4
2.7
2.3
Time (Hours)
***
-Nyxol+LDP (n=43)
***
4.4
3.3
*** 3.1
Nyxol+LDP arm statistically
significant compared to all arms
3
2.5
-Nyxol (n=30)
***
HH
***
I
***
4
4.4
3.3
3.3
2.7
Placebo + LDP (n=31)
Source: VEGA-1 TLR Table 14.2.12.1 Observed Values and Change from Baseline in Photopic Pupil Diameter by Time Point (PP Population)
LO
**p<0.01
***p<0.0001
5
3.3
Both components maintained
dynamic pupillary response
***
3.6 ***
2.9
4.6
6
Ocuphire
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