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GWAS: The Initial Foundation for Genome Analysis >>> >>> Single Nucleotide Polymorphism (SNP) GGCCAGCTGGACGAGG GGCCAGCTGGAT GAGG Cases Controls On GWAS = Genome-Wide Association Study SNPs associated with disease found at different frequencies in case vs controls Extensive know-how required to get from association to therapeutic target -log10 (pvalue) 200 100 50- 20- 10 5 2 3 4 9022 5 6 7 8 9 10 11 MEA 110.2 Copyright © 2024 23and Me, Inc. FEMINISTADEL 14 16 18 20 22 X T SNPs are tested across the genome and disease associations mapped to specific regions 23and Me 9

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