Kymera Investor Presentation Deck

Mean % Change in EASI Score (+/-S.E. of Mean) -10 20 -30 -40 -50 -60 KT-474 AD: Significant Reduction in EASI Score and Pruritus KYMERA 0 Mean % Change in EASI Score Over Time (N=7) 0 7 14 -17.9 21 Day -37.1 28 35 -27.6 -36.4 ©2023 KYMERA THERAPEUTICS, INC. 42 Mean % Change (+/-S.E. of Mean) 10 -10 -20 -40 -50 -70 -80 0 Mean % Change of Worst Pruritus Over Time (N=7) -5.8 H 7 -6.6 -32.1 14 -33.3 -43 | H H -35.6 -44.6 -51.2 21 Day 28 Past Week Past 24 Hours -38.9 -44.6 35 -51.9 -62.9 42 % of Pruritis Responders (80% CI) 100 90 80 70 50 30 20 10 O Patients with ≥4 Unit Reduction from Baseline in Worst Pruritus (N=7) 0 7 29 14 43 29 21 Day 71 Past Week Past 24 Hours 57 28 57 43 35 IRAK4 Patients 71 57 42 PAGE 16

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