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IMNM Autoantibodies Weakness and Loss of Grip Strength IgG purified from plasma from anti-SRP and anti-HMGCR IMNM patients causes loss of grip strength and muscle weakness in recipient mice A Grip strength (g) -20- 40- -60- argenx 아이에 n 0 100 dod *** Control IgG IgG-depleted plasma (P3) Anti-SRP* IgG (P3) Muscle strength (g) 120- 100- 80- 60- Bergua et al., Ann Rheum Dis. 2018 from Patient Serum Induce Muscle 0 H Control IgG • Anti-HMGCR* IgG (P4) Necrosis and complement deposition are observed similarly in recipient mice as in IMNM patients NECROSIS C5b-9 COMPLEMENT DEPOSITION x400 x400 34

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