Evotec Investor Day Presentation Deck

evotec ~8-10% of women in reproductive age PAGE 36 Two more large indications already on their way P2X3 | Eliapixant (BAY1817080) – Endometriosis // Overactive bladder (OAB) Endometriosis - No proper diagnosis • Estrogen-dependent, chronic inflammatory disease caused by endometrial tissue outside the uterus • Øage at first diagnosis 28 years Symptoms include dyspareunia, cyclic menstrual pain, chronic pelvic pain, subfertility Current treatment options . No safe & efficacious long-term treatment available • No non-hormonal treatments available Status: Phase II expected to be initiated shortly Sources: Ahn S et al. (2015). Pathophysiology and Immune Dysfunction in Endometriosis. Biomed Res Int. 2015;2015:795976 Alimi Y et al. (2018). The Clinical Anatomy of Endometriosis. A Review. Cureus. 2018 Sep; 10(9): e3361. Wee-Stekly et al. (2015). Endometriosis: A review of the diagnosis and pain management. Gynecology and Minimally Invasive Therapy G -12% of adults worldwide OAB- Growing topic with ageing population 1)2)3) • First line: behavioral training . Second line: medications e.g. anticholinergics • Third line: e.g. onabotulinumtoxin • Urinary urgency, with or without urinary incontinence. Usually with urinary frequency and nocturia4),5) Standard of Care Status: Phase II initiated September 2020 BAYER ¹) MedScape: https://emedicine.medscape.com/article/459340-guidelines (retrieved March 2020). 2) MedScape: https://emedicine.medscape.com/article/459340-overview#a1 (retrieved March 2020). 3) Mayoclinic: https://www.mayoclinic.org/diseases-conditions/overactive-bladder/symptoms-causes/syc-20355715 (retrieved March 2020). 4) Milsom I, Abrams P, Cardozo L, Roberts RG, Thüroff J, Wein AJ. How widespread are the symptoms of an overactive bladder and how are they managed 5) Irwin DE, Milsom I, Hunskaar S, et al. Population-based survey of urinary incontinence BAYER

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