Bionomics Investor Presentation Deck

300 mg BNC210 Demonstrated Acute Anxiolytic Activity in GAD Phase 2 Fearful Faces 24 GAD Patients 4 WAY CROSSOVER Significantly reduced activation of L & R amygdala caused by viewing fearful faces (L: p<0.05; R: p<0.01) Bionomics BNC210 300 mg BNC210 2000 mg Lorazepam 1.5 mg Placebo Contrast estimate Significantly reduced connectivity between amygdala and ACC while viewing fearful faces (p<0.05) 1.0 0.8 0.6 0.4 0.2 0.0 -0.2 Placebo Seed hemisphere Left Right fMRI Monitoring 300 mg 0.5 0.4- 0.3- 0.2 Significantly reduced threat avoidance behavior of anxious subjects in the JORT behavioral task Mean Intensity of Defensive Behavior 0.1- 0.0 Performed 'JORT' Placebo P=0.165 Lorazepam P=0.007 300 mg Error Bars SEM = BNC210 Wise T. et al., Biological Psychiatry 2020 (https://doi.org/10.1016/j.biopsych.2019.12.013); Perkins A. et al., Translational Psychiatry 2021 (https://doi.org/10.1038/s41398-020-01141-5) GAD = Generalized Anxiety Disorder JORT=Joystick Operated Runway Task fMRI = Functional Magnetic Resonance Imaging Amygdala activation is an imaging surrogate for anxiety Connectivity between the amygdala and Anterior Cingulate Cortex (ACC) is very strong in high anxiety P=0.033 2000 mg 10

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