Ocuphire Pharma Investor Day Presentation Deck
RM
44
Current Off-Label Landscape for RM
Physicians AVOID Use of Cholinergic Agonists (Pilocarpine) Due to the Risk on Ciliary Muscle
2 Classes of Mydriatic Agents
Phenylephrine
(a1 agonist)
Sympathetic (primarily a1)
innervation stimulates
the iris dilator muscles
Tropicamide
(anti-cholinergic)
Parasympathetic
innervation stimulates
the iris sphincter and
ciliary muscle
Lens
Corneal
Pupil
Iris
Ciliary
muscle
Reversal via the Ciliary Muscle by Cholinergic
Agonists* is Not a 'Safe' Option
1. Optician (2012)- Mydriatic Drugs: Practical Considerations
2. Pilocarpine FDA Label (2017)
3. Lee DA, Higginbotham EJ, 2005. Glaucoma and its treatment: a review. Am J Health Syst Pharm 62, 691-699.
X
X
X
Induces accommodation spasm and reduction in
distance vision¹
Induced anterior shift of the lens can increase the
risk of acute angle-closure glaucoma¹
High incidence of brow ache and headache
following installation³
Retinal tear has been reported in some patients²
* Cholinergic Agonists include pilocarpine,
carbachol, and aceclidine. Note, pilocarpine is rarely
used off-label for RM given these safety concerns.
Nyxol® is the only eye drop in clinical development for multiple indications
that does not affect the ciliary muscle
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