Taysha IPO Presentation Deck

Lafora disease is a fatal disorder of glycogen metabolism Teenage onset disease, severe neurodegenerative epilepsy Caused by mutations in either EPM2A (laforin) or EPM2B (malin) Progressive and invariably fatal, leading to death 5-10 years after onset The estimated prevalence of Lafora disease is 700 patients in the US and EU AAV9+ AAV9 I DA hEPM2A+ hEPM2B+ 倉 NO Intrathecal delivery Intrathecal delivery Number of EPM2A And EPM2B Cases According To Ethnicity/Country Glycogen EPM2A or EPM2B mutation Laforin Malin ..... Lafora body Lafora disease 55

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