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SeaSpine Investor Update

● ● +15 Product Launches & Line Extensions WaveForm® 3D IBD Explorer® Expandable IBD Mariner® Adult Deformity MIS Navigation Integrated FLASH™ Navigation tools OsteoTorrent™ DBMS Meridian >$60M Free Cash Flow Burn >$42M Investment in Inventory & Spinal Implant Sets >$2M Outflow on Final EMEA SI Stocking Orders - C 3 YEAR Extension of Credit Facility & $10M Expansion & Completed July 2022 Ⓒ2022 SeaSpine Orthopedics Corporation. All rights reserved | 21 Guidance 2022 Financial guidance information is as of August 2, 2022, based on guidance provided by SeaSpine leadership on that date. Inclusion of this information in this presentation is not a confirmation or an update of, and should not be construed or otherwise assumed to reflect any confirmation or update of, that guidance by SeaSpine leadership as of any date other than August 2, 2022. SeaSpine
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