Comera Investor Presentation Deck

● ● ● Binding kinetics and mechanism of stabilizers Interaction of stabilizers with mAbs was investigated using BLI octet Infliximab was biotinylated and loaded onto SSA tips. Binding kinetics determined by direct interaction with up to 1M stabilizers Kd calculated as 5.7 m M for CS1 and 6.9 for CS4 (44) Supay #16 At 412 KO ** 11 Se 400 mM CS1 200 mM CS1 100 mM CS1 800 mM CS4 400 mM CS4 200 mM CS4 100 mM CS4 50 mM CS4 Some CS1 binding kinetics Firmwa CS4 binding kinetics Se 1 S Comera LIFE SCIENCES 14

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