Vaxcyte Corporate Presentation

Global Impact of Pneumococcal Disease Remains Significant о About Streptococcus Pneumoniae Streptococcus pneumoniae is the most common pathogen causing pneumococcal disease (PD). Global Incidence and Impact of PD Global incidence of PD is driven by emerging serotypes not covered by currently available vaccines. Current Global Standard-of-Care (SOC) Vaccinations are recommended globally for infants and adults to prevent PD. Non-invasive PD includes: otitis media, sinusitis, pneumonia. Invasive PD (IPD) includes: bacteremia, meningitis. Pneumococci cause over 50% of all cases of bacterial meningitis in the U.S. In the U.S. alone, there are ~900K pneumococcal pneumonia cases annually. For IPD, adult mortality rates in the U.S. range from 11% to 30%. Among children under age 5, PD is a leading cause of death globally. In the U.S.: Infants: PCV13 (4 doses) Adults: Prevnar 20 TM (PCV20) (1 dose) or Vaxneuvance TM (PCV15) and Pneumovax 23Ⓡ (PPV23) (1 dose/each) 6 1 Gierke 2015 2 https://www.cdc.gov/abcs/reports-findings/survreports/spneu 18.pdf CDC 2018 https://www.cdc.gov/pneumococcal/clinicians/clinical-features.html

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