Ocuphire Pharma Investor Presentation Deck
Diabetic Eye Disease is Common Cause of Blindness
Diabetes and Diabetic Retinopathy (DR)
Diabetes Mellitus is a group of diseases characterized by
high blood glucose levels. Diabetes results from defects in
the body's ability to produce and/or use insulin
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Type 1 diabetes (T1D): The body produces very little
or no insulin, which means that patients need daily
insulin injections to maintain blood glucose levels
Type 2 diabetes (T2D): The most common form of
diabetes either the body does not produce enough
insulin, or resists insulin
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https://webeye.ophth.uiowa.edu/eyeforum/tutorials/diabetic-retinopathy-med-students/Classification.htm
https://www.mayoclinic.org/diseases-conditions/type-1-diabetes/symptoms-causes/syc-20353011
https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/symptoms-causes/syc-20351193
Diabetic retinopathy (DR) occurs when fluctuations or
instability in blood glucose levels damages blood vessels
in the retina
Normal Retina
Diabetic Retina
Two Types of DR
Non-Proliferative Diabetic Retinopathy (NPDR) - most common form
of DR - early stages of edema and exudates, blurred central vision
Proliferative Diabetic Retinopathy (PDR) - later stage of DR, marked
by abnormal blood vessels and scar tissue on retina
Diabetic Macular Edema (DME) can occur at any stage of DR
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