Ocuphire Pharma Investor Update

RM Mean Pupil Diameter (mm) 21 9 8 4 Mydriatic 3 Mean Pupil Diameter Over Time by Mydriatic Agents Nyxol Reduced PD With All Mydriatic Agents; More Rapidly with Phenylephrine as Expected -1 p=0.001 H p<0.0001 0 0.5 Mean PD Phenylephrine ㅏㅓ Max Dilation; Treatment p<0.0001 1 1 p<0.0001 2 H p<0.0001 3 p<0.0001 4 Placebo (n=74) -Nyxol (n=146) 1 1.5 Time Post-Treatment with Nyxol/Placebo (Hours) 5 p<0.0001 6 MIRA-3 Phase 3 Trial Mean PD - Study Eye (mITT) p<0.0001 24 Mean Pupil Diameter (mm) 9 8 LO 4 Mydriatic 3 -1 Max Dilation; Treatment p<0.0001 Mean PD - Tropicamide or Paremyd Placebo (n=50) -Nyxol (n=98) 0 0.5 H p<0.0001 p<0.0001 H FH p<0.0001 p<0.0001 3 HA 1 1.5 2 Time Post-Treatment with Nyxol/Placebo (Hours) 4 5 Source: MIRA-3 Table 14.2.2.3. (mITT). The p-values are change from max pupil dilation treatment compared to placebo. Standard Error bars are shown. FH p<0.0001 6 p<0.0001 24 Ocuphire PHARMA

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