Equillium Results Presentation Deck

Proteinuria/Albuminuria: Surrogate Markers for Renal Survival Proteinuria/Albuminuria cause renal damage and fibrosis and are markers of disease activity Early, rapid and deep reductions in proteinuria minimize kidney damage and are predictive of better renal outcomes Goal of treatment is to minimize kidney damage and progression to renal failure, preventing the need for renal replacement therapy • Reduction of proteinuria is used by regulatory authorities for approval of new glomerulonephritis therapies, including in lupus nephritis equillium Prognosis of CKD by GFR and Albuminuria Categories: KDIGO 2012 GFR categories (ml/min/1.73 m²) Description and range G1 G2 G3a G3b G4 G5 Normal or high Mildly decreased Mildly to moderately decreased Moderately to severely decreased Severely decreased Kidney failure 290 60-89 45-59 30-44 15-29 <15 Persistent albuminuria categories Description and range A1 Normal to mildly increased <30 mg/g <3 mg/mmol A2 Moderately increased 30-300 mg/g 3-30 mg/mmol A3 Severely increased >300 mg/g >30 mg/mmol Rovin et al. Kidney International, 2021, Levey et al AJKD, 2020, Rovin et al., The Lancet, 2021; Furie et al., NEJM, 2020; KDIGO (Kidney Disease Improving Global Outcomes) 2012 guidelines CKD evaluation and management

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