Eleusis SPAC
Psilocin Receptor Occupancy, Drug Intensity, and Treatment Effect: Academic Studies
Psilocin concentration
was correlated with serotonin
5-HT₂A receptor occupancy¹
2A
5-HT2AR occupancy (%)
100-
75-
50
25-
0-
eleusis
5
10
ELE-Psilo
Target Range
15
20
Plasma psilocin concentration (µg/L)
Subject 1 (3 mg)
Subject 2 (6 mg)
Subject 3 (12 mg)
Subject 4 (15 mg)
5-HT2A receptor occupancy
was correlated with
volunteer-reported drug intensity¹
Intensity rating
10.0-
7.5-
5.0-
2.5-
0.0-
Subject 5 (18 mg)
-Subject 6 (24 mg)
20
40
Occupancy (%)
Subject 7 (24 mg)
Subject 8 (30 mg)
60
80
Patient-reported
psychedelic drug
intensity was
correlated with the
antidepressant effects
of psilocybin ³,4 and
5-MeO-DMT5
Source: 1) Madsen, M. K. et al. (2019). Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels. Neuropsychopharmacology, 44(7), 1328-1334; 2) Brown, R. T. et al. (2017).
Pharmacokinetics of Escalating Doses of Oral Psilocybin in Healthy Adults. Clinical Pharmacokinetics, 56(12), 1543-1554 3) Yaden, D. B., & Griffiths, R. R. (2021). The Subjective Effects of Psychedelics Are Necessary for Their
Enduring Therapeutic Effects. ACS Pharmacology and Translational Science; 4) Davis, A. K., et al. (2020). Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder. JAMA Psychiatry. 5) GH Research Ltd. Press Release 16
"GH Research Announces Successful Outcome of the Phase 2 part of its Phase 1/2 Clinical Trial of GH001 in Treatment-Resistant Depression", 12/6/2021View entire presentation