Kymera IPO Presentation Deck

IRAK4 Degradation Superior to Kinase Inhibition in Intracellular Signaling KYMERA Phosphorylation events upon TLR activations monitored using flow cytometry KT-474 inhibited pro- inflammatory phosphorylation events in a superior manner to small-molecule inhibitors including clinically active PF-compound Unstim Ctrl R848 (TLR7/8) IRAKASMI IRAKA SMI (other) (PF-06550833) LPS (TLR4) IRAKASMI IRAK4 SMI (other) (PF-06550833)

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