Investor Presentation

5 X Focus on the Endocannabinoid System (ECS) The ECS is a master-regulator of inflammation and fibrosis Broad applicability Target for rational drug design CB1 Brain Lungs Vascular System Muscles Gastrointestinal Tract Reproductive Organs Immune System Liver Bone Marrow Pancreas CB2 Spleen Bones Skin Immune System Liver Bone Marrow Pancreas Well-understood biology GPCR Binding EM EMN Ceramide ERK, JNK, p38 CB1, CB2 FAN Gi/o By a do PI3K. PKB/Akt AC AMPC Ca¹2 N. P/Q Ca+2 K' channel type A PKA FAK H OH ...H Endocannabinoid System OH ||||

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